Cisplatin, also referred to chemically as cis-diamminechloroplatinum,
is a member of the therapeutic category of medicines known as Cytotoxic
medicines and is more specifically referred to as a Alkylating agent
and is commonly used in chemotherapy for the treatment of several
different types of cancer. http://www.tajaccura.com/product/cisplatin-injection-bp-10mg/
Cisplatin was the very first member of the class of medicines now referred to as Platinum-containing anti-cancer drugs[1]. Cisplatin has since been joined in this class by Carboplatin and Oxaliplatin. Cisplatin along with the other members of this class act as Platinum complexes which react in vivo to bind to DNA resulting in crosslinking of DNA and triggering programmed cell death
Cisplatin injections are available from Taj Accura Pharmaceuticals in dosages of 10, 50 and 100 mg.
What is Cisplatin used for?
Cisplatin injection, as an alkylating agent, is utilised either as a mono-therapy or a poly-therapy in the treatment of a number of different types of cancer including[2]:
Cisplatin interferes with cancer cell growth but can also affect the growth of normal body cells causing potential for side effects which should be reported to a doctor
How does Cisplatin work?
Cisplatin has been successfully used in chemotherapy regimens for over 35 years but its precise biochemical mechanism of action still has not been fully elucidated[3] (3).
The most commonly accepted mechanism however is that it possesses its cytotoxic effect as a result of binding to the nuclear DNA of cancerous cells and interfering with normal transcription and/or mechanisms need for the replication of DNA. The Cisplatin-DNA adducts are not processed efficiently by the machinery inside the cell eventually leading to cell death
Are there any side effects associated with the use of Methotrexate?
Yes, as with all medication there is a possibility that the patient may experience side effects but not everyone experiences them. Patients are advised to contact their doctor, pharmacist or nurse if they have any questions regarding treatment with Cisplatin.
Cisplatin is a very toxic medicine and is capable of causing serious illness or even death so any side effects experienced should be reported to a doctor. Some of these side effects include allergic symptoms such as flushing, wheezing, rash, swelling of the face, reduced blood pressure and increased heart rate.
How is Cisplatin Injection given?
Cisplatin injections are administered intravenously (into a vein) under strict direction of hospital specialists. Cisplatin in powder form is dissolved to form a solution. The resulting solution is then added to either a salt solution or alternatively a salt and sugar solution which is given into the blood stream over a set amount of time, usually over 6 to 8 hours.
The dose administered is dependent on the body surface area of the patient’s body and the type of cancer being treated. The patient receives 1 to 2 litres of fluid via infusion between 8 and 12 hours before Cisplatin is administered in order to increase the production and passing of urine. This is in order maintain diuresis for 24 hours after the Cisplatin is received.
Conclusion
Cisplatin Injections, for the treatment of testicular, cervical, ovarian, lung and bladder cancer, are available from Taj Accura Pharmaceuticals at strengths of 10, 50 and 100 mg. Always remember to consult your Doctor or Healthcare Professional if you have any questions about your own health or medications.
Always remember to consult your Doctor or Healthcare Professional if you have any questions about your own health or medications.
Taj Accura Pharmaceuticals are committed to providing affordable pharmaceutical care solutions to health providers and patients globally. Our enthusiastic and highly skilled bi-lingual sales team in English and French are more than welcome to take your queries. We are contactable by emailing info@tajaccura, by phone at + 353 (1) 293 1882 or alternatively by fax at + 353 (1) 293 1883
[1] MG Apps EC, NJ Wheate. The state-of-play and future of platinum drugs. Endocr Relat Cancer. 2015;22(4):219-33.
[2] MayoClinic. Cisplatin (Intravenous Route) Mayo Foundation for Medical Education and Research2015
[3] MA Fuertes JC, C Alonso, JM Pérez. Cisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways. Curr Med Chem. 2003;10(3):257-66.
Cisplatin was the very first member of the class of medicines now referred to as Platinum-containing anti-cancer drugs[1]. Cisplatin has since been joined in this class by Carboplatin and Oxaliplatin. Cisplatin along with the other members of this class act as Platinum complexes which react in vivo to bind to DNA resulting in crosslinking of DNA and triggering programmed cell death
Cisplatin injections are available from Taj Accura Pharmaceuticals in dosages of 10, 50 and 100 mg.
What is Cisplatin used for?
Cisplatin injection, as an alkylating agent, is utilised either as a mono-therapy or a poly-therapy in the treatment of a number of different types of cancer including[2]:
- Cancer of the Bladder
- Cancer of the Testicles
- Cancer of the Ovaries
- Cancer of the Cervix
- Cancer of the Lung
Cisplatin interferes with cancer cell growth but can also affect the growth of normal body cells causing potential for side effects which should be reported to a doctor
How does Cisplatin work?
Cisplatin has been successfully used in chemotherapy regimens for over 35 years but its precise biochemical mechanism of action still has not been fully elucidated[3] (3).
The most commonly accepted mechanism however is that it possesses its cytotoxic effect as a result of binding to the nuclear DNA of cancerous cells and interfering with normal transcription and/or mechanisms need for the replication of DNA. The Cisplatin-DNA adducts are not processed efficiently by the machinery inside the cell eventually leading to cell death
Are there any side effects associated with the use of Methotrexate?
Yes, as with all medication there is a possibility that the patient may experience side effects but not everyone experiences them. Patients are advised to contact their doctor, pharmacist or nurse if they have any questions regarding treatment with Cisplatin.
Cisplatin is a very toxic medicine and is capable of causing serious illness or even death so any side effects experienced should be reported to a doctor. Some of these side effects include allergic symptoms such as flushing, wheezing, rash, swelling of the face, reduced blood pressure and increased heart rate.
How is Cisplatin Injection given?
Cisplatin injections are administered intravenously (into a vein) under strict direction of hospital specialists. Cisplatin in powder form is dissolved to form a solution. The resulting solution is then added to either a salt solution or alternatively a salt and sugar solution which is given into the blood stream over a set amount of time, usually over 6 to 8 hours.
The dose administered is dependent on the body surface area of the patient’s body and the type of cancer being treated. The patient receives 1 to 2 litres of fluid via infusion between 8 and 12 hours before Cisplatin is administered in order to increase the production and passing of urine. This is in order maintain diuresis for 24 hours after the Cisplatin is received.
Conclusion
Cisplatin Injections, for the treatment of testicular, cervical, ovarian, lung and bladder cancer, are available from Taj Accura Pharmaceuticals at strengths of 10, 50 and 100 mg. Always remember to consult your Doctor or Healthcare Professional if you have any questions about your own health or medications.
Always remember to consult your Doctor or Healthcare Professional if you have any questions about your own health or medications.
Taj Accura Pharmaceuticals are committed to providing affordable pharmaceutical care solutions to health providers and patients globally. Our enthusiastic and highly skilled bi-lingual sales team in English and French are more than welcome to take your queries. We are contactable by emailing info@tajaccura, by phone at + 353 (1) 293 1882 or alternatively by fax at + 353 (1) 293 1883
[1] MG Apps EC, NJ Wheate. The state-of-play and future of platinum drugs. Endocr Relat Cancer. 2015;22(4):219-33.
[2] MayoClinic. Cisplatin (Intravenous Route) Mayo Foundation for Medical Education and Research2015
[3] MA Fuertes JC, C Alonso, JM Pérez. Cisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways. Curr Med Chem. 2003;10(3):257-66.
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